InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spint1

Summary

InnateDB Protein

IDBP-259441.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spint1

Protein Name

serine protease inhibitor, Kunitz type 1

Synonyms

HAI-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106441

InnateDB Gene

IDBG-199130 (Spint1)

Protein Structure

UniProt Annotation

Function

Inhibitor of HGF activator. {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0001892	embryonic placenta development
GO:0010951	negative regulation of endopeptidase activity
GO:0030198	extracellular matrix organization
GO:0060670	branching involved in labyrinthine layer morphogenesis
GO:0060674	placenta blood vessel development

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

MGI:1338033

InterPro

IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR002223 Proteinase inhibitor I2, Kunitz metazoa
IPR011106 Seven cysteines, N-terminal
IPR013980 Seven cysteines

PFAM

PF00057
PF00014
PF07502

PRINTS

PR00261
PR00759

PIRSF

SMART

SM00192
SM00131
SM00765

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt