Version 5.4
| Mus musculus Gene: Prkacb | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-199561.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Prkacb | ||||||||||||||||||||||
| Gene Name | protein kinase, cAMP dependent, catalytic, beta | ||||||||||||||||||||||
| Synonyms | Pkacb | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000005034 | ||||||||||||||||||||||
| Encoded Proteins |
protein kinase, cAMP dependent, catalytic, beta
protein kinase, cAMP dependent, catalytic, beta
protein kinase, cAMP dependent, catalytic, beta
protein kinase, cAMP dependent, catalytic, beta
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142875:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2011] The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 3:146729579-146812960 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | H2 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
Innate Immune System pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
Disease pathway
Hemostasis pathway
Signaling by GPCR pathway
Glucagon signaling in metabolic regulation pathway
Hedgehog 'off' state pathway
Integration of energy metabolism pathway
Ca-dependent events pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Signaling by FGFR in disease pathway
DARPP-32 events pathway
PLC-gamma1 signalling pathway
PKA-mediated phosphorylation of CREB pathway
Glucose metabolism pathway
Metabolism pathway
CREB phosphorylation through the activation of Adenylate Cyclase pathway
PKA activation in glucagon signalling pathway
Immune System pathway
EGFR interacts with phospholipase C-gamma pathway
Post NMDA receptor activation events pathway
Metabolism of lipids and lipoproteins pathway
Aquaporin-mediated transport pathway
Regulation of insulin secretion pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
CaM pathway pathway
Lipid digestion, mobilization, and transport pathway
Factors involved in megakaryocyte development and platelet production pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Degradation of GLI2 by the proteasome pathway
Signaling by EGFR pathway
Degradation of GLI1 by the proteasome pathway
GLI3 is processed to GLI3R by the proteasome pathway
Rap1 signalling pathway
Phospholipase C-mediated cascade pathway
Gluconeogenesis pathway
Transmembrane transport of small molecules pathway
Glycogen storage diseases pathway
PKA-mediated phosphorylation of key metabolic factors pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
Neuronal System pathway
DAG and IP3 signaling pathway
Signaling by Hedgehog pathway
NGF signalling via TRKA from the plasma membrane pathway
Opioid Signalling pathway
Calmodulin induced events pathway
Signal Transduction pathway
Transmission across Chemical Synapses pathway
Signaling by FGFR pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
PLC beta mediated events pathway
G-protein mediated events pathway
Myoclonic epilepsy of Lafora pathway
Signaling by EGFR in Cancer pathway
PKA activation pathway
Metabolism of carbohydrates pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
Taste transduction pathway
Olfactory transduction pathway
Insulin signaling pathway pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Wnt signaling pathway pathway
Gap junction pathway
GnRH signaling pathway pathway
MAPK signaling pathway pathway
Long-term potentiation pathway
Hedgehog signaling pathway pathway
Apoptosis pathway
Parkinson's disease pathway
Chemokine signaling pathway pathway
Vascular smooth muscle contraction pathway
Prion diseases pathway
Dilated cardiomyopathy pathway
Progesterone-mediated oocyte maturation pathway
Oocyte meiosis pathway
Vasopressin-regulated water reabsorption pathway
Amoebiasis pathway
Gastric acid secretion pathway
Salivary secretion pathway
Bile secretion pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
PKA activation pathway
PKA-mediated phosphorylation of CREB pathway
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Rap1 signalling pathway
Factors involved in megakaryocyte development and platelet production pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
PLC beta mediated events pathway
DARPP-32 events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
Gluconeogenesis pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Regulation of insulin secretion pathway
PKA activation in glucagon signalling pathway
Glucagon signaling in metabolic regulation pathway
PKA-mediated phosphorylation of key metabolic factors pathway
Integration of energy metabolism pathway
CREB phosphorylation through the activation of Adenylate Cyclase pathway
Signaling by FGFR in disease pathway
Transmembrane transport of small molecules pathway
Signalling by NGF pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Metabolism of lipids and lipoproteins pathway
Myoclonic epilepsy of Lafora pathway
Neuronal System pathway
Signaling by VEGF pathway
Metabolism of carbohydrates pathway
Signaling by GPCR pathway
Innate Immune System pathway
Degradation of GLI2 by the proteasome pathway
GLI3 is processed to GLI3R by the proteasome pathway
Degradation of GLI1 by the proteasome pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
Post NMDA receptor activation events pathway
G-protein mediated events pathway
Adaptive Immune System pathway
Immune System pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Lipid digestion, mobilization, and transport pathway
Ca-dependent events pathway
Aquaporin-mediated transport pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
Hemostasis pathway
Degradation of GLI1 by the proteasome pathway
DAP12 interactions pathway
Aquaporin-mediated transport pathway
Signaling by EGFR pathway
PLCG1 events in ERBB2 signaling pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Metabolism of carbohydrates pathway
Regulation of insulin secretion pathway
Post NMDA receptor activation events pathway
Factors involved in megakaryocyte development and platelet production pathway
PKA-mediated phosphorylation of CREB pathway
Signaling by GPCR pathway
Signaling by PDGF pathway
GLI3 is processed to GLI3R by the proteasome pathway
DARPP-32 events pathway
Calmodulin induced events pathway
DAG and IP3 signaling pathway
PLC-gamma1 signalling pathway
Signaling by FGFR pathway
CREB phosphorylation through the activation of Adenylate Cyclase pathway
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
Myoclonic epilepsy of Lafora pathway
Hemostasis pathway
Immune System pathway
Integration of energy metabolism pathway
Transmission across Chemical Synapses pathway
PKA-mediated phosphorylation of key metabolic factors pathway
EGFR interacts with phospholipase C-gamma pathway
Transmembrane transport of small molecules pathway
Signaling by ERBB2 pathway
Degradation of GLI2 by the proteasome pathway
Signal Transduction pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
Signaling by EGFR in Cancer pathway
Hedgehog 'off' state pathway
G-protein mediated events pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism of lipids and lipoproteins pathway
Gluconeogenesis pathway
Glycogen storage diseases pathway
NGF signalling via TRKA from the plasma membrane pathway
PLC beta mediated events pathway
Glucose metabolism pathway
Downstream signaling of activated FGFR pathway
Neuronal System pathway
Metabolism pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Signalling by NGF pathway
PKA activation pathway
Adaptive Immune System pathway
Signaling by Hedgehog pathway
Phospholipase C-mediated cascade pathway
PKA activation in glucagon signalling pathway
Downstream signal transduction pathway
Opioid Signalling pathway
Glucagon signaling in metabolic regulation pathway
Rap1 signalling pathway
Innate Immune System pathway
Ca-dependent events pathway
CaM pathway pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
Lipid digestion, mobilization, and transport pathway
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| KEGG |
GnRH signaling pathway pathway
Vibrio cholerae infection pathway
Gap junction pathway
Wnt signaling pathway pathway
Olfactory transduction pathway
Hedgehog signaling pathway pathway
Apoptosis pathway
MAPK signaling pathway pathway
Long-term potentiation pathway
Insulin signaling pathway pathway
Taste transduction pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Parkinson's disease pathway
Vascular smooth muscle contraction pathway
Chemokine signaling pathway pathway
Prion diseases pathway
Progesterone-mediated oocyte maturation pathway
Dilated cardiomyopathy pathway
Vasopressin-regulated water reabsorption pathway
Oocyte meiosis pathway
Gastric acid secretion pathway
Amoebiasis pathway
Salivary secretion pathway
Bile secretion pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
VEGF signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
GPCR signaling pathway
Hedgehog signaling pathway pathway
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| PID NCI |
p75(NTR)-mediated signaling
p73 transcription factor network
Alpha4 beta1 integrin signaling events
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| Cross-References | |||||||||||||||||||||||
| SwissProt | P68181 | ||||||||||||||||||||||
| TrEMBL | Q8C4J3 Q8CBP8 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 18749 | ||||||||||||||||||||||
| UniGene | Mm.16766 Mm.475261 | ||||||||||||||||||||||
| RefSeq | NM_001164200 NM_001164198 NM_001164199 NM_011100 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS51092 CCDS17906 CCDS51090 CCDS51091 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | MGI:97594 | ||||||||||||||||||||||
| MGI Symbol | Prkacb | ||||||||||||||||||||||
| EMBL | AF022239 AK035560 AK048319 AK081984 AK139419 AK148728 AK150122 AK150134 AK163585 BC054533 J02626 M21096 X61434 | ||||||||||||||||||||||
| GenPept | AAA39938 AAA39941 AAH54533 BAC29106 BAC33301 BAC38388 BAE24005 BAE28648 BAE29323 BAE29331 BAE37407 CAA43676 | ||||||||||||||||||||||
| RNA Seq Atlas | 18749 | ||||||||||||||||||||||