InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mul1

Summary

InnateDB Gene

IDBG-199848.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mul1

Gene Name

mitochondrial ubiquitin ligase activator of NFKB 1

Synonyms

0610009K11Rik; AV000801; Gide

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041241

Encoded Proteins

IDBP-199850

mitochondrial ubiquitin ligase activator of NFKB 1

IDBP-270067

mitochondrial ubiquitin ligase activator of NFKB 1

IDBP-270071

mitochondrial ubiquitin ligase activator of NFKB 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23399697

[Homo sapiens] MUL1 limits inflammation by regulating the RIG-I anti-viral response.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090432:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:138434671-138442265

Strand

Forward strand

Band

Transcripts

ENSMUST00000044058	ENSMUSP00000039604
ENSMUST00000105815	ENSMUSP00000101441
ENSMUST00000105813	ENSMUSP00000101439

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019789	SUMO ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding

Biological Process

GO:0000266	mitochondrial fission
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007005	mitochondrion organization
GO:0007257	activation of JUN kinase activity
GO:0010637	negative regulation of mitochondrial fusion
GO:0016567	protein ubiquitination
GO:0016925	protein sumoylation
GO:0030308	negative regulation of cell growth
GO:0033235	positive regulation of protein sumoylation
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824	negative regulation of innate immune response
GO:0050689	negative regulation of defense response to virus by host
GO:0050821	protein stabilization
GO:0051646	mitochondrion localization
GO:0051898	negative regulation of protein kinase B signaling
GO:0060339	negative regulation of type I interferon-mediated signaling pathway
GO:0071360	cellular response to exogenous dsRNA
GO:0071650	negative regulation of chemokine (C-C motif) ligand 5 production
GO:0090141	positive regulation of mitochondrial fission
GO:1901028	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0016020	membrane
GO:0031307	integral component of mitochondrial outer membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000090432

View Gene Order

ENSBTAG00000020850

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.103413

RefSeq

NM_026689 XM_006539134

OMIM

CCDS

CCDS18828

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas