InnateDB Protein
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IDBP-270067.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mul1
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Protein Name
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mitochondrial ubiquitin ligase activator of NFKB 1
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Synonyms
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0610009K11Rik; AV000801; Gide;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000101441
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InnateDB Gene
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IDBG-199848 (Mul1)
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Protein Structure
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Function |
Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its abilty to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination (By similarity). {ECO:0000250}.
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Subcellular Localization |
Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Peroxisome {ECO:0000250}. Note=Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
17 [view]
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Molecular Function |
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Biological Process |
GO:0000266
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mitochondrial fission
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GO:0006919
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activation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0007257
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activation of JUN kinase activity
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GO:0010637
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negative regulation of mitochondrial fusion
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GO:0016567
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protein ubiquitination
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GO:0016925
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protein sumoylation
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GO:0030308
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negative regulation of cell growth
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GO:0033235
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positive regulation of protein sumoylation
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GO:0043123
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positive regulation of I-kappaB kinase/NF-kappaB signaling
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GO:0045824
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negative regulation of innate immune response
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GO:0050689
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negative regulation of defense response to virus by host
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GO:0050821
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protein stabilization
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GO:0051646
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mitochondrion localization
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GO:0051898
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negative regulation of protein kinase B signaling
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GO:0060339
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negative regulation of type I interferon-mediated signaling pathway
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GO:0071360
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cellular response to exogenous dsRNA
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GO:0071650
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negative regulation of chemokine (C-C motif) ligand 5 production
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GO:0090141
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positive regulation of mitochondrial fission
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GO:1901028
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regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
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Cellular Component |
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PDB ID |
MGI:1915600
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VCM5
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PhosphoSite |
PhosphoSite-Q8VCM5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
68350
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UniGene |
Mm.103413
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RefSeq |
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MGI ID |
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MGI Symbol |
Mul1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK002416
AK044088
AK076419
AK083295
AK153956
AK170149
AL807249
BC019516
EU935009
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GenPept |
AAH19516
ACH72646
BAB22084
BAC31768
BAC36332
BAC38848
BAE32279
BAE41597
CAM18879
CAM18880
CAM18881
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