InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Abcb10

Summary

InnateDB Gene

IDBG-199895.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcb10

Gene Name

ATP-binding cassette, sub-family B (MDR/TAP), member 10

Synonyms

Abc-me; Abcb12

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031974

Encoded Proteins

IDBP-199897

ATP-binding cassette, sub-family B (MDR/TAP), member 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene localizes to the mitochondrial inner membrane. The specific function of this transporter has not been determined; however, it is likely that it may involve critical mitochondrial transport related to heme biosynthesis. [provided by RefSeq, Jul 2008]
This gene encodes a member of the ATP-binding cassette superfamily of transporters. ATP-binding cassette proteins transport various molecules across extra- and intra-cellular membranes. The encoded protein is localized to the mitochondrial inner membrane where it interacts with and stabilizes mitoferrin-1, and is important for heme biosynthesis. Additional evidence suggests the encoded protein is involved in oxidative stress protection and erythropoisesis. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:123952459-123983122

Strand

Reverse strand

Band

Transcripts

ENSMUST00000075578

ENSMUSP00000075011

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0042803	protein homodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane
GO:0032592	integral component of mitochondrial membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000135776

View Gene Order

ENSBTAG00000017053

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu02010

ABC transporters pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_111108

Mitochondrial ABC transporters pathway

REACT_15480

ABC-family proteins mediated transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

KEGG

hsa02010

ABC transporters pathway

INOH

PID NCI

Cross-References

SwissProt

Q9JI39

TrEMBL

UniProt Splice Variant

Entrez Gene

56199

UniGene

Mm.274243

RefSeq

NM_019552 XM_006531201

OMIM

CCDS

CCDS22766

HPRD

IMGT

MGI ID

MGI:1860508

MGI Symbol

Abcb10

EMBL

AF266284 AK081782 BC046818 BC053020 BC054793

GenPept

AAF76889 AAH46818 AAH53020 AAH54793 BAC38331

RNA Seq Atlas

56199