InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abcb10

Summary

InnateDB Protein

IDBP-199897.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcb10

Protein Name

ATP-binding cassette, sub-family B (MDR/TAP), member 10

Synonyms

Abc-me; Abcb12;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075011

InnateDB Gene

IDBG-199895 (Abcb10)

Protein Structure

UniProt Annotation

Function

May mediate critical mitochondrial transport functions related to heme biosynthesis.

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed at particularly high levels in fetal liver, and erythroid tissues of embryos and adults. Found also in adult bone marrow, liver and kidney, and at lower levels in heart, brain and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0042803	protein homodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane
GO:0032592	integral component of mitochondrial membrane

Protein Structure and Domains

PDB ID

MGI:1860508

InterPro

IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JI39