InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Taf5l

Summary

InnateDB Gene

IDBG-199943.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Taf5l

Gene Name

TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor

Synonyms

1110005N04Rik; AI849020

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038697

Encoded Proteins

IDBP-199945

TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor

IDBP-624253

TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135801:
The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:123996318-124021309

Strand

Reverse strand

Band

Transcripts

ENSMUST00000093039	ENSMUSP00000090726
ENSMUST00000165628	ENSMUSP00000128710

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043966	histone H3 acetylation

Cellular Component

GO:0005634	nucleus
GO:0030914	STAGA complex
GO:0033276	transcription factor TFTC complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000135801

View Gene Order

ENSBTAG00000034225

Not yet available

Pathways

NETPATH

REACTOME

REACT_218274

Chromatin organization pathway

REACT_226917

HATs acetylate histones pathway

REACT_202766

Chromatin modifying enzymes pathway

KEGG

mmu03022

Basal transcription factors pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_172610

HATs acetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

hsa03022

Basal transcription factors pathway

INOH

PID NCI

Cross-References

SwissProt

Q91WQ5

TrEMBL

Q3U3C7

UniProt Splice Variant

Entrez Gene

102162

UniGene

Mm.291777 Mm.409769 Mm.490582

RefSeq

NM_133966 XM_006530546

OMIM

CCDS

CCDS22767

HPRD

IMGT

MGI ID

MGI:1919039

MGI Symbol

Taf5l

EMBL

AK033477 AK089463 AK154832 BC013550

GenPept

AAH13550 BAC28309 BAC40894 BAE32861

RNA Seq Atlas

102162