Version 5.4
Mus musculus Gene: Soat1
Summary
InnateDB Gene IDBG-200307.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Soat1
Gene Name sterol O-acyltransferase 1
Synonyms 8430426K15Rik; Acact; ACAT-1; ald; AW550831; hid
Species Mus musculus
Ensembl Gene ENSMUSG00000026600
Encoded Proteins
IDBP-200309
sterol O-acyltransferase 1
IDBP-788630
sterol O-acyltransferase 1
IDBP-788631
sterol O-acyltransferase 1
IDBP-788632
sterol O-acyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000057252:
The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:156424525-156474331
Strand Reverse strand
Band G3
Transcripts
ENSMUST00000051396 ENSMUSP00000058344
ENSMUST00000189661 ENSMUSP00000140721
ENSMUST00000186420
ENSMUST00000187987
ENSMUST00000191379
ENSMUST00000187507 ENSMUSP00000139431
ENSMUST00000187073
ENSMUST00000188027 ENSMUSP00000141074
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0004772 sterol O-acyltransferase activity
GO:0005515 protein binding
GO:0015485 cholesterol binding
GO:0034736 cholesterol O-acyltransferase activity
Biological Process
GO:0008203 cholesterol metabolic process
GO:0010742 macrophage derived foam cell differentiation
GO:0010878 cholesterol storage
GO:0033344 cholesterol efflux
GO:0034379 very-low-density lipoprotein particle assembly
GO:0034435 cholesterol esterification
GO:0042986 positive regulation of amyloid precursor protein biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000057252
View Gene Order
ENSBTAG00000004059
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00100
Steroid biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00100
Steroid biosynthesis pathway
INOH
INOH website
Steroids metabolism pathway
PID NCI
Cross-References
SwissProt Q61263
TrEMBL
UniProt Splice Variant
Entrez Gene 20652
UniGene Mm.28099 Mm.402249 Mm.488792
RefSeq NM_009230 XM_006496719
OMIM
CCDS CCDS35743
HPRD
IMGT
MGI ID MGI:104665
MGI Symbol Soat1
EMBL AK142486 AK159393 AK159529 AK160017 BC083092 L42293 S81092
GenPept AAB36050 AAC42075 AAH83092 BAE25081 BAE35047 BAE35158 BAE35563
RNA Seq Atlas 20652

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca