InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Soat1

Summary

InnateDB Protein

IDBP-200309.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Soat1

Protein Name

sterol O-acyltransferase 1

Synonyms

8430426K15Rik; Acact; ACAT-1; ald; AW550831; hid;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058344

InnateDB Gene

IDBG-200307 (Soat1)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0004772	sterol O-acyltransferase activity
GO:0015485	cholesterol binding
GO:0034736	cholesterol O-acyltransferase activity

Biological Process

GO:0008203	cholesterol metabolic process
GO:0010742	macrophage derived foam cell differentiation
GO:0010878	cholesterol storage
GO:0033344	cholesterol efflux
GO:0034379	very-low-density lipoprotein particle assembly
GO:0034435	cholesterol esterification
GO:0042986	positive regulation of amyloid precursor protein biosynthetic process