Mus musculus Gene: Msh4
Summary
InnateDB Gene IDBG-200535.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Msh4
Gene Name mutS homolog 4 (E. coli)
Synonyms 4930485C04Rik; AV144863; mMsh4
Species Mus musculus
Ensembl Gene ENSMUSG00000005493
Encoded Proteins
mutS homolog 4 (E. coli)
mutS homolog 4 (E. coli)
mutS homolog 4 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000057468:
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:153857149-153906138
Strand Reverse strand
Band H3
Transcripts
ENSMUST00000005630 ENSMUSP00000005630
ENSMUST00000191083
ENSMUST00000189189
ENSMUST00000186220
ENSMUST00000191504
ENSMUST00000191606
ENSMUST00000188338 ENSMUSP00000140190
ENSMUST00000190449 ENSMUSP00000140265
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
GO:0030983 mismatched DNA binding
Biological Process
GO:0001541 ovarian follicle development
GO:0006200 ATP catabolic process
GO:0006298 mismatch repair
GO:0007126 meiotic nuclear division
GO:0007129 synapsis
GO:0007131 reciprocal meiotic recombination
GO:0007283 spermatogenesis
GO:0007292 female gamete generation
GO:0045143 homologous chromosome segregation
GO:0051026 chiasma assembly
Cellular Component
GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0000795 synaptonemal complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Meiotic Recombination pathway
Mus musculus biological processes pathway
Cell Cycle pathway
Meiosis pathway
Meiotic recombination pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Meiotic recombination pathway
Cell Cycle pathway
Meiosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q99MT2
TrEMBL A6H6D5 Q7TMA3 Q7TNA0
UniProt Splice Variant
Entrez Gene 55993
UniGene Mm.272226
RefSeq NM_001282054 NM_031870 XM_006501725
OMIM
CCDS CCDS38678
HPRD
IMGT
MGI ID MGI:1860077
MGI Symbol Msh4
EMBL AF178957 AF298655 AY351588 AY351589 AY351591 BC138163 BC145838 CH466532
GenPept AAI38164 AAI45839 AAK15620 AAL18350 AAQ20791 AAQ20793 AAQ20797 EDL11904
RNA Seq Atlas 55993