Version 5.4
Bos taurus Gene: MSH4
Summary
InnateDB Gene IDBG-637739.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSH4
Gene Name mutS protein homolog 4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018448
Encoded Proteins
IDBP-689767
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000057468:
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:69221074-69302542
Strand Reverse strand
Band
Transcripts
ENSBTAT00000024552 ENSBTAP00000024552
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
Biological Process
GO:0001541 ovarian follicle development
GO:0006298 mismatch repair
GO:0007126 meiotic nuclear division
GO:0007129 synapsis
GO:0007283 spermatogenesis
GO:0007292 female gamete generation
Cellular Component
GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0000795 synaptonemal complex
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000057468
View Gene Order
ENSMUSG00000005493
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_27271
Meiotic recombination pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
REACT_27235
Meiotic Recombination pathway
REACT_200794
Mus musculus biological processes pathway
REACT_188804
Cell Cycle pathway
REACT_198624
Meiosis pathway
REACT_198629
Meiotic recombination pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.112403
RefSeq NM_001206255 XM_005204417
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca