Version 5.4
Mus musculus Gene: Pla2g4d
Summary
InnateDB Gene IDBG-200549.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pla2g4d
Gene Name phospholipase A2, group IVD
Synonyms 2610311B01Rik; cPLA2delta; Pla2delta
Species Mus musculus
Ensembl Gene ENSMUSG00000070719
Encoded Proteins
IDBP-200551
phospholipase A2, group IVD
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159337:
The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:120265595-120289197
Strand Reverse strand
Band E5
Transcripts
ENSMUST00000094665 ENSMUSP00000092252
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004620 phospholipase activity
GO:0004623 phospholipase A2 activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0008152 metabolic process
GO:0009395 phospholipid catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030659 cytoplasmic vesicle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159337
View Gene Order
ENSBTAG00000005268
Not yet available
Pathways
NETPATH
REACTOME
REACT_199038
Acyl chain remodelling of PC pathway
REACT_199039
Acyl chain remodelling of PG pathway
REACT_199030
Acyl chain remodelling of PS pathway
REACT_199022
Hydrolysis of LPC pathway
REACT_199027
Acyl chain remodelling of PE pathway
REACT_199024
Acyl chain remodelling of PI pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188640
Synthesis of PA pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
mmu00564
Glycerophospholipid metabolism pathway
mmu04370
VEGF signaling pathway pathway
mmu00590
Arachidonic acid metabolism pathway
mmu00565
Ether lipid metabolism pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu04912
GnRH signaling pathway pathway
mmu00591
Linoleic acid metabolism pathway
mmu04010
MAPK signaling pathway pathway
mmu00592
alpha-Linolenic acid metabolism pathway
mmu04730
Long-term depression pathway
mmu04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120829
Acyl chain remodelling of PC pathway
REACT_120722
Acyl chain remodelling of PI pathway
REACT_120977
Hydrolysis of LPC pathway
REACT_121384
Acyl chain remodelling of PS pathway
REACT_120906
Synthesis of PA pathway
REACT_121324
Acyl chain remodelling of PG pathway
REACT_121369
Acyl chain remodelling of PE pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00592
alpha-Linolenic acid metabolism pathway
hsa04912
GnRH signaling pathway pathway
hsa00590
Arachidonic acid metabolism pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa00564
Glycerophospholipid metabolism pathway
hsa00591
Linoleic acid metabolism pathway
hsa04730
Long-term depression pathway
hsa00565
Ether lipid metabolism pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt Q50L43
TrEMBL
UniProt Splice Variant
Entrez Gene 78390
UniGene Mm.330507
RefSeq NM_001024137 XM_006500413 XM_006500414
OMIM
CCDS CCDS16617
HPRD
IMGT
MGI ID MGI:1925640
MGI Symbol Pla2g4d
EMBL AB195276 AK145985 AK167492 AL844608
GenPept BAD98152 BAE26807 BAE39570 CAM19514
RNA Seq Atlas 78390

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca