Version 5.4
| Mus musculus Protein: Pla2g4d | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-200551.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Pla2g4d | ||||||||||
| Protein Name | phospholipase A2, group IVD | ||||||||||
| Synonyms | 2610311B01Rik; cPLA2delta; Pla2delta; | ||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Protein | ENSMUSP00000092252 | ||||||||||
| InnateDB Gene | IDBG-200549 (Pla2g4d) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions. {ECO:0000269PubMed:15866882}. | ||||||||||
| Subcellular Localization | Cytoplasm, cytosol {ECO:0000269PubMed:15866882}. Cytoplasmic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Translocates to membrane vesicles in a calcium-dependent fashion. Translocates to perinuclear regions upon ionomycin stimulation. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | Weakly or not expressed in most tissues. Detected in placenta of 17.5 dpc embryos. {ECO:0000269PubMed:15866882}. | ||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | MGI:1925640 | ||||||||||
| InterPro |
IPR000008
C2 domain IPR002642 Lysophospholipase, catalytic domain IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase |
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| PFAM |
PF00168
PF01735 |
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| PRINTS |
PR00360
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| PIRSF | |||||||||||
| SMART |
SM00239
SM00022 |
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| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q50L43 | ||||||||||
| PhosphoSite | PhosphoSite-Q50L43 | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 78390 | ||||||||||
| UniGene | Mm.330507 | ||||||||||
| RefSeq | NP_001019308 | ||||||||||
| MGI ID | |||||||||||
| MGI Symbol | Pla2g4d | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS16617 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | AB195276 AK145985 AK167492 AL844608 | ||||||||||
| GenPept | BAD98152 BAE26807 BAE39570 CAM19514 | ||||||||||