Version 5.4
| Mus musculus Gene: Crk | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-200571.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Crk | ||||||||||||||||||||||
| Gene Name | v-crk sarcoma virus CT10 oncogene homolog (avian) | ||||||||||||||||||||||
| Synonyms | c-Crk; Crk-I; Crk-II; Crk-III; Crk3; CrkIII; Crko; p38 | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000017776 | ||||||||||||||||||||||
| Encoded Proteins |
v-crk sarcoma virus CT10 oncogene homolog (avian)
v-crk sarcoma virus CT10 oncogene homolog (avian)
v-crk sarcoma virus CT10 oncogene homolog (avian)
v-crk sarcoma virus CT10 oncogene homolog (avian)
v-crk sarcoma virus CT10 oncogene homolog (avian)
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In mouse this protein is essential for embryonic development. Alternatively spliced transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Mar 2013] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 11:75679259-75706908 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | B5 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 239 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Innate Immune System pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Hemostasis pathway
Signaling by Insulin receptor pathway
Signaling by VEGF pathway
Cytokine Signaling in Immune system pathway
Signal attenuation pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Downstream signal transduction pathway
Insulin receptor signalling cascade pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
Signaling by Interleukins pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Signalling by NGF pathway
Signaling by PDGF pathway
p130Cas linkage to MAPK signaling for integrins pathway
NGF signalling via TRKA from the plasma membrane pathway
ARMS-mediated activation pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
Prolonged ERK activation events pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
Regulation of signaling by CBL pathway
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| KEGG |
Renal cell carcinoma pathway
ErbB signaling pathway pathway
Insulin signaling pathway pathway
Regulation of actin cytoskeleton pathway
MAPK signaling pathway pathway
Chronic myeloid leukemia pathway
Focal adhesion pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Bacterial invasion of epithelial cells pathway
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| INOH |
Integrin signaling pathway pathway
HGF signaling pathway pathway
PDGF signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
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| REACTOME |
Regulation of actin dynamics for phagocytic cup formation pathway
Regulation of signaling by CBL pathway
Interleukin-3, 5 and GM-CSF signaling pathway
p130Cas linkage to MAPK signaling for integrins pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
ARMS-mediated activation pathway
Signal attenuation pathway
Signaling by Insulin receptor pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Signalling by NGF pathway
Signaling by VEGF pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Immune System pathway
Insulin receptor signalling cascade pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Prolonged ERK activation events pathway
Hemostasis pathway
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| KEGG |
Regulation of actin cytoskeleton pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
MAPK signaling pathway pathway
Insulin signaling pathway pathway
Focal adhesion pathway
Chronic myeloid leukemia pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Bacterial invasion of epithelial cells pathway
Shigellosis pathway
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| INOH |
Integrin signaling pathway pathway
HGF signaling pathway pathway
PDGF signaling pathway pathway
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| PID NCI |
EPHA forward signaling
E-cadherin signaling in the nascent adherens junction
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
LPA receptor mediated events
CXCR4-mediated signaling events
VEGFR3 signaling in lymphatic endothelium
Signaling events mediated by PTP1B
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Nectin adhesion pathway
Signaling events mediated by focal adhesion kinase
IGF1 pathway
EPHB forward signaling
RAC1 signaling pathway
Endothelins
Angiopoietin receptor Tie2-mediated signaling
Signaling events regulated by Ret tyrosine kinase
Alpha4 beta1 integrin signaling events
PDGFR-alpha signaling pathway
PDGFR-beta signaling pathway
Insulin Pathway
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| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Mm.280125 Mm.441530 Mm.472542 Mm.487139 | ||||||||||||||||||||||
| RefSeq | NM_001277219 NM_001277221 NM_133656 XM_006532125 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS25055 CCDS70241 CCDS70242 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||