InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Crk

Summary

InnateDB Protein

IDBP-200573.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crk

Protein Name

v-crk sarcoma virus CT10 oncogene homolog (avian)

Synonyms

c-Crk; Crk-I; Crk-II; Crk-III; Crk3; CrkIII; Crko; p38;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000017920

InnateDB Gene

IDBG-200571 (Crk)

Protein Structure

UniProt Annotation

Function

The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocated to the plasma membrane upon cell adhesion. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 239 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	40 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	239 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0030674	protein binding, bridging
GO:0042169	SH2 domain binding
GO:0045309	protein phosphorylated amino acid binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0009967	positive regulation of signal transduction
GO:0032319	regulation of Rho GTPase activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0035020	regulation of Rac protein signal transduction
GO:0048013	ephrin receptor signaling pathway