InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Abcg5

Summary

InnateDB Gene

IDBG-200680.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcg5

Gene Name

ATP-binding cassette, sub-family G (WHITE), member 5

Synonyms

AW112016; cmp; sterolin-1; trac

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040505

Encoded Proteins

IDBP-200682

ATP-binding cassette, sub-family G (WHITE), member 5

IDBP-621875

ATP-binding cassette, sub-family G (WHITE), member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. In humans, this protein functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols; however, the function of the mouse gene has not been determined. Mutations in the human gene have been associated with sterol accumulation, atheroschlerosis, and sitosterolemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:84658234-84683011

Strand

Reverse strand

Band

Transcripts

ENSMUST00000066175	ENSMUSP00000069495
ENSMUST00000163375	ENSMUSP00000130783
ENSMUST00000171544
ENSMUST00000172439

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0017127	cholesterol transporter activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0007584	response to nutrient
GO:0007588	excretion
GO:0010212	response to ionizing radiation
GO:0010949	negative regulation of intestinal phytosterol absorption
GO:0030299	intestinal cholesterol absorption
GO:0033344	cholesterol efflux
GO:0042493	response to drug
GO:0042632	cholesterol homeostasis
GO:0045796	negative regulation of intestinal cholesterol absorption