InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abcg5

Summary

InnateDB Protein

IDBP-200682.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcg5

Protein Name

ATP-binding cassette, sub-family G (WHITE), member 5

Synonyms

AW112016; cmp; sterolin-1; trac;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069495

InnateDB Gene

IDBG-200680 (Abcg5)

Protein Structure

UniProt Annotation

Function

Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the intestine and, at lower level, in the liver. {ECO:0000269PubMed:11099417}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0017127	cholesterol transporter activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0007584	response to nutrient
GO:0007588	excretion
GO:0010212	response to ionizing radiation
GO:0010949	negative regulation of intestinal phytosterol absorption
GO:0030299	intestinal cholesterol absorption
GO:0033344	cholesterol efflux
GO:0042493	response to drug
GO:0042632	cholesterol homeostasis
GO:0045796	negative regulation of intestinal cholesterol absorption

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

MGI:1351659

InterPro

IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR013525 ABC-2 type transporter
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00005
PF01061

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99PE8