InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lrpprc

Summary

InnateDB Gene

IDBG-200763.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrpprc

Gene Name

leucine-rich PPR-motif containing

Synonyms

3110001K13Rik; C76645; Gp130; Lrp130; Lsfc

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024120

Encoded Proteins

IDBP-256275

leucine-rich PPR-motif containing

IDBP-537100

leucine-rich PPR-motif containing

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138095:
This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:84705247-84790789

Strand

Reverse strand

Band

Transcripts

ENSMUST00000112308	ENSMUSP00000107927
ENSMUST00000162799
ENSMUST00000160011	ENSMUSP00000123795
ENSMUST00000160414
ENSMUST00000161928
ENSMUST00000161299
ENSMUST00000159222

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003697	single-stranded DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0000961	negative regulation of mitochondrial RNA catabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0051028	mRNA transport
GO:0070129	regulation of mitochondrial translation

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0005634	nucleus
GO:0005637	nuclear inner membrane
GO:0005640	nuclear outer membrane
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0042645	mitochondrial nucleoid
GO:0048471	perinuclear region of cytoplasm