InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cryz

Summary

InnateDB Gene

IDBG-200786.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cryz

Gene Name

crystallin, zeta

Synonyms

Sez9

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028199

Encoded Proteins

IDBP-200788

crystallin, zeta

IDBP-537176

crystallin, zeta

IDBP-541465

crystallin, zeta

IDBP-539846

crystallin, zeta

IDBP-536634

crystallin, zeta

IDBP-789689

crystallin, zeta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116791:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:154596711-154623182

Strand

Forward strand

Band

Transcripts

ENSMUST00000029850	ENSMUSP00000029850
ENSMUST00000155385	ENSMUSP00000122619
ENSMUST00000135723
ENSMUST00000140644	ENSMUSP00000115146
ENSMUST00000144764	ENSMUSP00000121269
ENSMUST00000155232	ENSMUSP00000118449
ENSMUST00000184537	ENSMUSP00000139387

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003730	mRNA 3'-UTR binding
GO:0003960	NADPH:quinone reductase activity
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0050661	NADP binding
GO:0070402	NADPH binding

Biological Process

GO:0042178	xenobiotic catabolic process
GO:0051289	protein homotetramerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000116791

View Gene Order

ENSBTAG00000003162

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.374855 Mm.489828

RefSeq

NM_009968 XM_006500973

OMIM

CCDS

CCDS17927

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas