InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CRYZ

Summary

InnateDB Gene

IDBG-99739.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRYZ

Gene Name

crystallin, zeta (quinone reductase)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000116791

Encoded Proteins

IDBP-99741

crystallin, zeta (quinone reductase)

IDBP-99743

crystallin, zeta (quinone reductase)

IDBP-99745

crystallin, zeta (quinone reductase)

IDBP-99747

crystallin, zeta (quinone reductase)

IDBP-385860

crystallin, zeta (quinone reductase)

IDBP-385861

crystallin, zeta (quinone reductase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:74705482-74733408

Strand

Reverse strand

Band

p31.1

Transcripts

ENST00000370872	ENSP00000359909
ENST00000340866	ENSP00000339399
ENST00000370871	ENSP00000359908
ENST00000370870	ENSP00000359907
ENST00000417775	ENSP00000399805
ENST00000441120	ENSP00000404289
ENST00000492102

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003730	mRNA 3'-UTR binding
GO:0003960	NADPH:quinone reductase activity
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0070402	NADPH binding

Biological Process

GO:0007601	visual perception
GO:0042178	xenobiotic catabolic process
GO:0051289	protein homotetramerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028199

View Gene Order

ENSBTAG00000003162

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q08257

TrEMBL

C9JH92

UniProt Splice Variant

Entrez Gene

1429

UniGene

Hs.699602 Hs.83114

RefSeq

NM_001130043 NM_001130042 NM_001134759 NM_001889 XM_005270491

HUGO

HGNC:2419

OMIM

123691

CCDS

CCDS44162 CCDS44163 CCDS665

HPRD

00437

IMGT

EMBL

AB209714 AC091611 AC135803 AK223150 AK223201 AK314813 BC039578 BC070058 BX647883 CH471059 L13278 L31521 L31522 L31523 L31524 L31525 L31526

GenPept

AAA36536 AAH39578 AAH70058 AAK40311 BAD92951 BAD96870 BAD96921 CAI46072 EAX06409 EAX06410 EAX06411 EAX06412

RNA Seq Atlas

1429