Version 5.4
Mus musculus Gene: Pappa2
Summary
InnateDB Gene IDBG-200797.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pappa2
Gene Name pappalysin 2
Synonyms PAPP-A2; Pappe; PLAC3
Species Mus musculus
Ensembl Gene ENSMUSG00000073530
Encoded Proteins
IDBP-540464
pappalysin 2
IDBP-535880
pappalysin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116183:
This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:158711727-158980490
Strand Reverse strand
Band H1
Transcripts
ENSMUST00000159861 ENSMUSP00000124022
ENSMUST00000161589 ENSMUSP00000124316
ENSMUST00000159860
ENSMUST00000160206
ENSMUST00000159892
ENSMUST00000177789
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0030154 cell differentiation
GO:0060349 bone morphogenesis
Cellular Component
GO:0005575 cellular_component
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116183
View Gene Order
ENSBTAG00000018303
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 23850
UniGene Mm.420800 Mm.458621
RefSeq NM_001085376 XM_006496822 XM_006496823 XM_006496824 XM_006496825
OMIM
CCDS CCDS48409
HPRD
IMGT
MGI ID MGI:3051647
MGI Symbol Pappa2
EMBL
GenPept
RNA Seq Atlas 23850

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca