Version 5.4
Homo sapiens Gene: SRP72
Summary
InnateDB Gene IDBG-20091.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRP72
Gene Name signal recognition particle 72kDa
Synonyms BMFF; BMFS1; HEL103
Species Homo sapiens
Ensembl Gene ENSG00000174780
Encoded Proteins
IDBP-20093
signal recognition particle 72kDa
IDBP-474752
signal recognition particle 72kDa
IDBP-812609
signal recognition particle 72kDa
IDBP-477641
signal recognition particle 72kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:56466915-56503680
Strand Forward strand
Band q12
Transcripts
ENST00000342756 ENSP00000342181
ENST00000510663 ENSP00000424576
ENST00000504757 ENSP00000473576
ENST00000505314 ENSP00000425190
ENST00000507126
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005047 signal recognition particle binding
GO:0005515 protein binding
GO:0008312 7S RNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0042493 response to drug
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005786 signal recognition particle, endoplasmic reticulum targeting
GO:0005829 cytosol
GO:0048500 signal recognition particle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036323
View Gene Order
ENSBTAG00000010593
Not yet available
Pathways
NETPATH
REACTOME
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_71
Gene Expression pathway
KEGG
hsa03060
Protein export pathway
INOH
PID NCI
Cross-References
SwissProt O76094
TrEMBL
UniProt Splice Variant
Entrez Gene 6731
UniGene Hs.537696 Hs.605767
RefSeq NM_001267722 NM_006947 XM_005265765
HUGO HGNC:11303
OMIM 602122
CCDS CCDS58898 CCDS3506
HPRD 03671
IMGT
EMBL AC114766 AF069765 AF077019 BX537991 CH471057
GenPept AAC27324 AAC97490 CAD97950 EAX05498
RNA Seq Atlas 6731

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca