Version 5.4
Homo sapiens Gene: LSP1
Summary
InnateDB Gene IDBG-20097.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LSP1
Gene Name lymphocyte-specific protein 1
Synonyms pp52; WP34
Species Homo sapiens
Ensembl Gene ENSG00000130592
Encoded Proteins
IDBP-20101
lymphocyte-specific protein 1
IDBP-20103
lymphocyte-specific protein 1
IDBP-292676
lymphocyte-specific protein 1
IDBP-292677
lymphocyte-specific protein 1
IDBP-361413
lymphocyte-specific protein 1
IDBP-361415
lymphocyte-specific protein 1
IDBP-361424
lymphocyte-specific protein 1
IDBP-361426
lymphocyte-specific protein 1
IDBP-361427
lymphocyte-specific protein 1
IDBP-361428
lymphocyte-specific protein 1
IDBP-361429
lymphocyte-specific protein 1
IDBP-361432
lymphocyte-specific protein 1
IDBP-811447
lymphocyte-specific protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:1852970-1892267
Strand Forward strand
Band p15.5
Transcripts
ENST00000311604 ENSP00000308383
ENST00000381775 ENSP00000371194
ENST00000405957 ENSP00000383932
ENST00000406638 ENSP00000384022
ENST00000421485 ENSP00000411191
ENST00000446808 ENSP00000402543
ENST00000451814 ENSP00000414106
ENST00000457279 ENSP00000400346
ENST00000429923 ENSP00000400999
ENST00000418975 ENSP00000403460
ENST00000417766 ENSP00000416363
ENST00000432093 ENSP00000412405
ENST00000472974
ENST00000485341
ENST00000484895
ENST00000464670
ENST00000612798 ENSP00000484140
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004871 signal transducer activity
Biological Process
GO:0006928 cellular component movement
GO:0006935 chemotaxis
GO:0006952 defense response
GO:0006968 cellular defense response
GO:0007165 signal transduction
Cellular Component
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018819
View Gene Order
ENSBTAG00000010447
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
p38_mk2pathway
p38 signaling mediated by MAPKAP kinases
Cross-References
SwissProt P33241
TrEMBL C9J9B9 C9JKF7 C9JNQ1 E9PBD8 Q9UEV7 Q9UEV8
UniProt Splice Variant
Entrez Gene 4046
UniGene Hs.56729 Hs.739234
RefSeq NM_001013253 XM_005252927 NM_001013254 NM_001013255 NM_001242932 NM_001289005 NM_002339 XM_005252924 XM_006718232
HUGO HGNC:6707
OMIM 153432
CCDS CCDS31335 CCDS31334 CCDS58110
HPRD 01083
IMGT
EMBL AC051649 AF043107 AF043349 AK056576 AK092071 AK222733 BC001785 CR541728 CR541754 M33552 S67783 X55188
GenPept AAA59534 AAB29545 AAB99825 AAC00495 AAH01785 BAD96453 BAG51753 BAG52478 CAA38971 CAG46529 CAG46554
RNA Seq Atlas 4046

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca