Version 5.4
Mus musculus Gene: Lsp1
Summary
InnateDB Gene IDBG-212561.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lsp1
Gene Name lymphocyte specific 1
Synonyms Lsp-1; p50; pp52; WP34
Species Mus musculus
Ensembl Gene ENSMUSG00000018819
Encoded Proteins
IDBP-212563
lymphocyte specific 1
IDBP-212565
lymphocyte specific 1
IDBP-269755
lymphocyte specific 1
IDBP-269757
lymphocyte specific 1
IDBP-269759
lymphocyte specific 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130592:
This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:142460809-142494867
Strand Forward strand
Band F5
Transcripts
ENSMUST00000018963 ENSMUSP00000018963
ENSMUST00000038946 ENSMUSP00000040637
ENSMUST00000105968 ENSMUSP00000101588
ENSMUST00000105967 ENSMUSP00000101587
ENSMUST00000105966 ENSMUSP00000101586
ENSMUST00000128986
ENSMUST00000132956
ENSMUST00000149521
ENSMUST00000140626
ENSMUST00000156960
ENSMUST00000126149
ENSMUST00000142408
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004871 signal transducer activity
Biological Process
GO:0006915 apoptotic process
GO:0006935 chemotaxis
GO:0006952 defense response
GO:0007010 cytoskeleton organization
GO:0007165 signal transduction
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130592
View Gene Order
ENSBTAG00000010447
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
p38_mk2pathway
p38 signaling mediated by MAPKAP kinases
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001136071 NM_001271508 NM_001271509 NM_001271510 NM_001271523 NM_019391 XM_006508494 XM_006508495 XM_006508496
OMIM
CCDS CCDS40193 CCDS52450 CCDS72072 CCDS72073
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca