InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FLT1

Summary

InnateDB Gene

IDBG-20108.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FLT1

Gene Name

fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

Synonyms

FLT; FLT-1; VEGFR-1; VEGFR1

Species

Homo sapiens

Ensembl Gene

ENSG00000102755

Encoded Proteins

IDBP-20110

fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

IDBP-589838

fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

IDBP-585667

fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

IDBP-595661

fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

IDBP-593550

fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

IDBP-811959

fms-related tyrosine kinase 1

IDBP-811963

fms-related tyrosine kinase 1

IDBP-811982

fms-related tyrosine kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:28300344-28495128

Strand

Reverse strand

Band

q12.3

Transcripts

ENST00000282397	ENSP00000282397
ENST00000540678	ENSP00000443311
ENST00000543394	ENSP00000437841
ENST00000541932	ENSP00000437631
ENST00000539099	ENSP00000442630
ENST00000615840	ENSP00000484039
ENST00000617835	ENSP00000484832
ENST00000615611	ENSP00000484385

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0036326	VEGF-A-activated receptor activity
GO:0036327	VEGF-B-activated receptor activity
GO:0036332	placental growth factor-activated receptor activity
GO:0042802	identical protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0002040	sprouting angiogenesis
GO:0002548	monocyte chemotaxis
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0010863	positive regulation of phospholipase C activity
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030154	cell differentiation
GO:0030335	positive regulation of cell migration
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0036323	vascular endothelial growth factor receptor-1 signaling pathway
GO:0043406	positive regulation of MAP kinase activity
GO:0043410	positive regulation of MAPK cascade
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045766	positive regulation of angiogenesis
GO:0046777	protein autophosphorylation
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048514	blood vessel morphogenesis
GO:0048598	embryonic morphogenesis