Version 5.4
Mus musculus Gene: Snap23
Summary
InnateDB Gene IDBG-201120.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Snap23
Gene Name synaptosomal-associated protein 23
Synonyms 23kDa; AA408749; SNAP-23; Sndt; Syndet
Species Mus musculus
Ensembl Gene ENSMUSG00000027287
Encoded Proteins
IDBP-201122
synaptosomal-associated protein 23
IDBP-259689
synaptosomal-associated protein 23
IDBP-274132
synaptosomal-associated protein 23
IDBP-542469
synaptosomal-associated protein 23
IDBP-537509
synaptosomal-associated protein 23
IDBP-532210
synaptosomal-associated protein 23
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18692471
[Homo sapiens] SNAP23 phosphorylation by IKBKB regulates mast cell degranulation and anaphylactic reactions.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092531:
Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:120567671-120601255
Strand Forward strand
Band E5
Transcripts
ENSMUST00000028743 ENSMUSP00000028743
ENSMUST00000110711 ENSMUSP00000106339
ENSMUST00000116437 ENSMUSP00000112138
ENSMUST00000150611 ENSMUSP00000119652
ENSMUST00000153580 ENSMUSP00000121509
ENSMUST00000147864
ENSMUST00000142278 ENSMUSP00000116935
ENSMUST00000137144
ENSMUST00000130759
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006887 exocytosis
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
GO:0031410 cytoplasmic vesicle
GO:0042581 specific granule
GO:0042582 azurophil granule
GO:0043005 neuron projection
GO:0045202 synapse
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000092531
View Gene Order
ENSBTAG00000005661
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_234979
Clathrin derived vesicle budding pathway
REACT_199054
Translocation of GLUT4 to the plasma membrane pathway
KEGG
mmu04130
SNARE interactions in vesicular transport pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04130
SNARE interactions in vesicular transport pathway
INOH
PID NCI
Cross-References
SwissProt O09044
TrEMBL A2AKH4 B0R029 B0R030
UniProt Splice Variant
Entrez Gene 20619
UniGene Mm.398640 Mm.413475
RefSeq NM_001177793 NM_001177792 NM_009222 XM_006499054 XM_006499055 XM_006499056
OMIM
CCDS CCDS16622 CCDS50681
HPRD
IMGT
MGI ID MGI:109356
MGI Symbol Snap23
EMBL AB000822 AB007444 AF007169 AF213251 AF213252 AF213253 AF213254 AF213255 AF213256 AF213257 AK019162 AL772299 BC070456 CH466519 U73143
GenPept AAB53597 AAB62932 AAF23503 AAH70456 BAA20345 BAB31577 BAF91555 EDL28001
RNA Seq Atlas 20619

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca