InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trex1

Summary

InnateDB Gene

IDBG-201128.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trex1

Gene Name

three prime repair exonuclease 1

Synonyms

1661; AU041952

Species

Mus musculus

Ensembl Gene

ENSMUSG00000049734

Encoded Proteins

IDBP-201130

three prime repair exonuclease 1

IDBP-256819

three prime repair exonuclease 1

IDBP-538563

three prime repair exonuclease 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213689:
This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
This gene encodes a nuclear protein with 3\' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:109057933-109060338

Strand

Reverse strand

Band

Transcripts

ENSMUST00000061973	ENSMUSP00000050971
ENSMUST00000112053	ENSMUSP00000107684
ENSMUST00000128062	ENSMUSP00000118499

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0004527	exonuclease activity
GO:0005515	protein binding
GO:0008296	3'-5'-exodeoxyribonuclease activity
GO:0008408	3'-5' exonuclease activity
GO:0008853	exodeoxyribonuclease III activity
GO:0032405	MutLalpha complex binding
GO:0032407	MutSalpha complex binding
GO:0032558	adenyl deoxyribonucleotide binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0000738	DNA catabolic process, exonucleolytic
GO:0006259	DNA metabolic process
GO:0035458	cellular response to interferon-beta
GO:0090305	nucleic acid phosphodiester bond hydrolysis