InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Epas1

Summary

InnateDB Gene

IDBG-201225.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epas1

Gene Name

endothelial PAS domain protein 1

Synonyms

bHLHe73; HIF-2alpha; HIF2A; HLF; HRF; MOP2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024140

Encoded Proteins

IDBP-201227

endothelial PAS domain protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116016:
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:86753907-86833410

Strand

Forward strand

Band

Transcripts

ENSMUST00000024954

ENSMUSP00000024954

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	96 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0035035	histone acetyltransferase binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0001892	embryonic placenta development
GO:0001974	blood vessel remodeling
GO:0002027	regulation of heart rate
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006979	response to oxidative stress
GO:0007005	mitochondrion organization
GO:0007165	signal transduction
GO:0007601	visual perception
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0030218	erythrocyte differentiation
GO:0030324	lung development
GO:0042415	norepinephrine metabolic process
GO:0043129	surfactant homeostasis
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048469	cell maturation
GO:0048625	myoblast fate commitment
GO:0071456	cellular response to hypoxia