InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rhoq

Summary

InnateDB Gene

IDBG-201284.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rhoq

Gene Name

ras homolog gene family, member Q

Synonyms

Arhq; Tc10; TC10A

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024143

Encoded Proteins

IDBP-201286

ras homolog gene family, member Q

IDBP-533652

ras homolog gene family, member Q

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119729:
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:86963082-87000069

Strand

Forward strand

Band

Transcripts

ENSMUST00000024956	ENSMUSP00000024956
ENSMUST00000139344	ENSMUSP00000116780

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005522	profilin binding
GO:0005525	GTP binding
GO:0032427	GBD domain binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0008286	insulin receptor signaling pathway
GO:0008360	regulation of cell shape
GO:0015031	protein transport
GO:0030036	actin cytoskeleton organization
GO:0030866	cortical actin cytoskeleton organization
GO:0032869	cellular response to insulin stimulus
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046325	negative regulation of glucose import
GO:0046326	positive regulation of glucose import
GO:0051491	positive regulation of filopodium assembly
GO:0090005	negative regulation of establishment of protein localization to plasma membrane