Version 5.4
Homo sapiens Gene: RHOQ
Summary
InnateDB Gene IDBG-50385.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHOQ
Gene Name ras homolog family member Q
Synonyms ARHQ; HEL-S-42; RASL7A; TC10; TC10A
Species Homo sapiens
Ensembl Gene ENSG00000119729
Encoded Proteins
IDBP-50387
ras homolog gene family, member Q
IDBP-374629
ras homolog gene family, member Q
IDBP-483360
ras homolog gene family, member Q
IDBP-482117
ras homolog gene family, member Q
IDBP-483170
ras homolog gene family, member Q
IDBP-808786
ras homolog family member Q
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:46541806-46583121
Strand Forward strand
Band p21
Transcripts
ENST00000238738 ENSP00000238738
ENST00000432183 ENSP00000393140
ENST00000465198
ENST00000489471 ENSP00000428624
ENST00000482449 ENSP00000428006
ENST00000473428 ENSP00000429003
ENST00000494370
ENST00000489448
ENST00000616091 ENSP00000484856
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005522 profilin binding
GO:0005525 GTP binding
GO:0032427 GBD domain binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0008286 insulin receptor signaling pathway
GO:0008360 regulation of cell shape
GO:0015031 protein transport
GO:0030866 cortical actin cytoskeleton organization
GO:0032869 cellular response to insulin stimulus
GO:0032956 regulation of actin cytoskeleton organization
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046326 positive regulation of glucose import
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051491 positive regulation of filopodium assembly
GO:0090005 negative regulation of establishment of protein localization to plasma membrane
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024143
View Gene Order
ENSBTAG00000013749
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04910
Insulin signaling pathway pathway
INOH
PID NCI
insulin_pathway
Insulin Pathway
insulin_glucose_pathway
Insulin-mediated glucose transport
Cross-References
SwissProt
TrEMBL F8WET9
UniProt Splice Variant
Entrez Gene 23433
UniGene Hs.577599 Hs.709193
RefSeq NM_012249
HUGO HGNC:17736
OMIM 605857
CCDS CCDS33191
HPRD 05791
IMGT
EMBL AC018682
GenPept
RNA Seq Atlas 23433

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca