InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sdhb

Summary

InnateDB Gene

IDBG-201440.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sdhb

Gene Name

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Synonyms

0710008N11Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000009863

Encoded Proteins

IDBP-201442

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117118:
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:140961203-140979193

Strand

Forward strand

Band

Transcripts

ENSMUST00000010007	ENSMUSP00000010007
ENSMUST00000129181
ENSMUST00000125780

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008177	succinate dehydrogenase (ubiquinone) activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0048039	ubiquinone binding
GO:0051536	iron-sulfur cluster binding
GO:0051537	2 iron, 2 sulfur cluster binding
GO:0051538	3 iron, 4 sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006105	succinate metabolic process
GO:0022904	respiratory electron transport chain
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005749	mitochondrial respiratory chain complex II
GO:0045273	respiratory chain complex II
GO:0070062	extracellular vesicular exosome