InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SDHB

Summary

InnateDB Gene

IDBG-91733.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SDHB

Gene Name

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Synonyms

CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP

Species

Homo sapiens

Ensembl Gene

ENSG00000117118

Encoded Proteins

IDBP-91735

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

IDBP-806406

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

IDBP-806407

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:17018722-17054170

Strand

Reverse strand

Band

p36.13

Transcripts

ENST00000375499	ENSP00000364649
ENST00000475049
ENST00000485092
ENST00000485515
ENST00000491274	ENSP00000480482
ENST00000475506
ENST00000463045	ENSP00000481376
ENST00000466613

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	47 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008177	succinate dehydrogenase (ubiquinone) activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0048039	ubiquinone binding
GO:0051536	iron-sulfur cluster binding
GO:0051537	2 iron, 2 sulfur cluster binding
GO:0051538	3 iron, 4 sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006105	succinate metabolic process
GO:0009060	aerobic respiration
GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005749	mitochondrial respiratory chain complex II
GO:0045273	respiratory chain complex II
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000009863

View Gene Order

ENSBTAG00000008314

Not yet available

Pathways

NETPATH

REACTOME

REACT_22393

Respiratory electron transport pathway

REACT_1785

Citric acid cycle (TCA cycle) pathway

REACT_1046

Pyruvate metabolism and Citric Acid (TCA) cycle pathway

REACT_6305

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

KEGG

hsa00020

Citrate cycle (TCA cycle) pathway

hsa05010

Alzheimer's disease pathway

hsa00190

Oxidative phosphorylation pathway

hsa05012

Parkinson's disease pathway

hsa05016

Huntington's disease pathway

INOH

INOH website

Arginine Proline metabolism pathway

INOH website

Citrate cycle pathway

INOH website

Tyrosine metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_003000

HUGO

OMIM

CCDS

CCDS176

HPRD

01707

IMGT

EMBL

GenPept

RNA Seq Atlas