Version 5.4
Mus musculus Gene: Slc15a4
Summary
InnateDB Gene IDBG-201520.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc15a4
Gene Name solute carrier family 15, member 4
Synonyms AA987064; AW742963; C130069N12Rik; PHT1; PTR4
Species Mus musculus
Ensembl Gene ENSMUSG00000029416
Encoded Proteins
IDBP-201522
solute carrier family 15, member 4
IDBP-536559
solute carrier family 15, member 4
IDBP-532880
solute carrier family 15, member 4
IDBP-537739
solute carrier family 15, member 4
IDBP-531804
solute carrier family 15, member 4
IDBP-538035
solute carrier family 15, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21045126
Slc15a4, a peptide/histidine transporter in organelle trafficking, is required for the production of pro-inflammatory cytokines in plasmacytoid dendritic cells upon recognition of viral nucleic acids by endosomal Tlr7 or Tlr9.
InnateDB Annotation from Orthologs
Summary
PMID 19570976
[Homo sapiens] SLC15A4 is an oligopeptide transporter expressed in early endosomes which is involved in transportation of NOD1 ligands.
PMID 21045126
[Homo sapiens] SLC15A4, a peptide/histidine transporter in organelle trafficking, is required for the production of pro-inflammatory cytokines in plasmacytoid dendritic cells upon recognition of viral nucleic acids by endosomal TLR7 or TLR9.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139370:
Gene Information
Type Protein coding
Genomic Location Chromosome 5:127595664-127632897
Strand Reverse strand
Band G1.2
Transcripts
ENSMUST00000031367 ENSMUSP00000031367
ENSMUST00000153832 ENSMUSP00000123116
ENSMUST00000124569 ENSMUSP00000121595
ENSMUST00000144603 ENSMUSP00000116420
ENSMUST00000152727 ENSMUSP00000116529
ENSMUST00000155321 ENSMUSP00000117258
ENSMUST00000182841
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005290 L-histidine transmembrane transporter activity
GO:0015293 symporter activity
Biological Process
GO:0006810 transport
GO:0006857 oligopeptide transport
GO:0015031 protein transport
GO:0015817 histidine transport
GO:0045087 innate immune response (InnateDB)
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000139370
View Gene Order
ENSBTAG00000009167
Not yet available
Pathways
NETPATH
REACTOME
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_251788
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_246374
Proton/oligonucleotide cotransporters pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19328
Proton/oligonucleotide cotransporters pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 100561
UniGene
RefSeq NM_133895 XM_006504272
OMIM
CCDS CCDS19688
HPRD
IMGT
MGI ID MGI:2140796
MGI Symbol Slc15a4
EMBL
GenPept
RNA Seq Atlas 100561

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca