Version 5.4
Mus musculus Gene: Camp
Summary
InnateDB Gene IDBG-201591.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Camp
Gene Name cathelicidin antimicrobial peptide
Synonyms CAP18; Cnlp; Cramp; FALL39; MCLP
Species Mus musculus
Ensembl Gene ENSMUSG00000038357
Encoded Proteins
IDBP-256913
cathelicidin antimicrobial peptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21448240
CAMP (LL-37), at sufficiently low concentrations, is able to reduce fungal infectivity by inhibiting C. albicans adhesion to plastic surfaces, oral epidermoid cells, and the urinary bladders of female mice. The inhibitory effects of LL-37 on cell adhesion and aggregation were mediated by its preferential binding to mannan and chitin in the fungal cell wall. (Demonstrated in human)
PMID 21464330
Camp (LL-37) translocates across the E. coli outer membrane and halts bacterial growth by interfering cell wall biogenesis. (Demonstrated in human)
PMID 21762664
Camp protects against colitis induction in mice. The increased expression of Camp in monocytes involves the activation of Tlr9/ERK signalling pathway by bacterial DNA.
PMID 21832078
Camp expression is induced upon endoplasmic reticulum stress via NF-kB-C/EBP-alpha activation. (Demonstrated in human)
PMID 22031815
mCRAMP (Camp) reduces influenza A viral load and disease severity in mice.
PMID 25554785
The transcription factor Zfp423 is necessary for adipocyte activation and impaired adipogenesis is observed in Zfp423(nur12) mice.
PMID 25896094
Camp plays an important role in the innate immune response against pathogens in bacterial central nervous system infections.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:109847375-109849456
Strand Reverse strand
Band F2
Transcripts
ENSMUST00000112022 ENSMUSP00000107653
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002227 innate immune response in mucosa
GO:0006952 defense response
GO:0008284 positive regulation of cell proliferation
GO:0019731 antibacterial humoral response
GO:0042742 defense response to bacterium
GO:0044130 negative regulation of growth of symbiont in host
GO:0044140 negative regulation of growth of symbiont on or near host surface
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0051873 killing by host of symbiont cells
GO:0071222 cellular response to lipopolysaccharide
GO:0071224 cellular response to peptidoglycan
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0042581 specific granule
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_198345
Phagosomal maturation (early endosomal stage) pathway
REACT_198347
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
KEGG
mmu04970
Salivary secretion pathway
INOH
PID NCI
Cross-References
SwissProt P51437
TrEMBL Q91VE7
UniProt Splice Variant
Entrez Gene 12796
UniGene Mm.3834
RefSeq NM_009921
OMIM
CCDS CCDS52934
HPRD
IMGT
MGI ID MGI:108443
MGI Symbol Camp
EMBL AB039064 AB039065 AB039066 AB039067 AB039068 AB039069 AB039070 AB039071 AF035680 BC120752 BC120754 U43409 X94353
GenPept AAA85898 AAB88303 AAI20753 AAI20755 BAB68588 BAB68589 BAB68590 BAB68591 BAB68592 BAB68593 BAB68594 BAB68595 CAA64078
RNA Seq Atlas 12796

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca