InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Camp

Summary

InnateDB Protein

IDBP-256913.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Camp

Protein Name

cathelicidin antimicrobial peptide

Synonyms

CAP18; Cnlp; Cramp; FALL39; MCLP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107653

InnateDB Gene

IDBG-201591 (Camp)

Protein Structure

UniProt Annotation

Function

Acts as a potent antimicrobial peptide.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in testis, spleen, stomach, and intestine. Very low expression found in heart, lung and skeletal muscle. No expression in brain, kidney or liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0002227	innate immune response in mucosa
GO:0006952	defense response
GO:0008284	positive regulation of cell proliferation
GO:0019731	antibacterial humoral response
GO:0042742	defense response to bacterium
GO:0044130	negative regulation of growth of symbiont in host
GO:0044140	negative regulation of growth of symbiont on or near host surface
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0051873	killing by host of symbiont cells
GO:0071222	cellular response to lipopolysaccharide
GO:0071224	cellular response to peptidoglycan
GO:0071347	cellular response to interleukin-1
GO:0071354	cellular response to interleukin-6
GO:0071356	cellular response to tumor necrosis factor

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0042581	specific granule
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome