Version 5.4
| Mus musculus Gene: Cdc25a | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-201603.7 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | Cdc25a | ||||||||||||
| Gene Name | cell division cycle 25A | ||||||||||||
| Synonyms | D9Ertd393e | ||||||||||||
| Species | Mus musculus | ||||||||||||
| Ensembl Gene | ENSMUSG00000032477 | ||||||||||||
| Encoded Proteins |
cell division cycle 25 homolog A (S. pombe)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| Entrez Gene | |||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164045:
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 9:109875579-109893888 | ||||||||||||
| Strand | Forward strand | ||||||||||||
| Band | F2 | ||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
p53-Independent G1/S DNA damage checkpoint pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
G0 and Early G1 pathway
p53-Independent DNA Damage Response pathway
Cell Cycle pathway
Cell Cycle Checkpoints pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
G2/M Checkpoints pathway
Mitotic G2-G2/M phases pathway
G1/S DNA Damage Checkpoints pathway
E2F-enabled inhibition of pre-replication complex formation pathway
Cyclin A/B1 associated events during G2/M transition pathway
G1/S Transition pathway
Mitotic G1-G1/S phases pathway
Activation of ATR in response to replication stress pathway
Cyclin B2 mediated events pathway
E2F mediated regulation of DNA replication pathway
Cyclin E associated events during G1/S transition pathway
S Phase pathway
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| KEGG |
Cell cycle pathway
Progesterone-mediated oocyte maturation pathway
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| INOH | |||||||||||||
| PID NCI | |||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||
| NETPATH |
AndrogenReceptor pathway
TGF_beta_Receptor pathway
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| REACTOME |
Activation of ATR in response to replication stress pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
p53-Independent DNA Damage Response pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
G0 and Early G1 pathway
G1/S-Specific Transcription pathway
Cyclin E associated events during G1/S transition pathway
E2F-enabled inhibition of pre-replication complex formation pathway
E2F mediated regulation of DNA replication pathway
Polo-like kinase mediated events pathway
Cyclin A/B1 associated events during G2/M transition pathway
Cyclin B2 mediated events pathway
p53-Independent G1/S DNA damage checkpoint pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G2/M Checkpoints pathway
G1/S Transition pathway
Cell Cycle pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
G1/S DNA Damage Checkpoints pathway
Mitotic G2-G2/M phases pathway
Cell Cycle Checkpoints pathway
G2/M Transition pathway
G0 and Early G1 pathway
E2F-enabled inhibition of pre-replication complex formation pathway
S Phase pathway
Mitotic G1-G1/S phases pathway
Cyclin A/B1 associated events during G2/M transition pathway
p53-Independent G1/S DNA damage checkpoint pathway
G1/S DNA Damage Checkpoints pathway
G1/S Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
E2F mediated regulation of DNA replication pathway
Cell Cycle pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
Cyclin E associated events during G1/S transition pathway
p53-Independent DNA Damage Response pathway
Cyclin B2 mediated events pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
G2/M Checkpoints pathway
Activation of ATR in response to replication stress pathway
Cell Cycle Checkpoints pathway
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| KEGG |
Cell cycle pathway
Progesterone-mediated oocyte maturation pathway
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| INOH | |||||||||||||
| PID NCI |
Validated targets of C-MYC transcriptional activation
E2F transcription factor network
ATM pathway
ATR signaling pathway
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| Cross-References | |||||||||||||
| SwissProt | P48964 | ||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 12530 | ||||||||||||
| UniGene | Mm.307103 Mm.399840 Mm.412309 | ||||||||||||
| RefSeq | NM_007658 XM_006511931 | ||||||||||||
| OMIM | |||||||||||||
| CCDS | CCDS23559 | ||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| MGI ID | MGI:103198 | ||||||||||||
| MGI Symbol | Cdc25a | ||||||||||||
| EMBL | CT573087 U27323 | ||||||||||||
| GenPept | AAA85580 | ||||||||||||
| RNA Seq Atlas | 12530 | ||||||||||||