InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDC25A

Summary

InnateDB Gene

IDBG-32204.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC25A

Gene Name

cell division cycle 25 homolog A (S. pombe)

Synonyms

CDC25A2

Species

Homo sapiens

Ensembl Gene

ENSG00000164045

Encoded Proteins

IDBP-32206

cell division cycle 25 homolog A (S. pombe)

IDBP-32208

cell division cycle 25 homolog A (S. pombe)

IDBP-375640

cell division cycle 25 homolog A (S. pombe)

IDBP-375642

cell division cycle 25 homolog A (S. pombe)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:48157146-48188402

Strand

Reverse strand

Band

p21.31

Transcripts

ENST00000302506	ENSP00000303706
ENST00000351231	ENSP00000343166
ENST00000443342	ENSP00000416483
ENST00000437972	ENSP00000404285
ENST00000459900

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.

Experimentally validated
Total	87 [view]
Protein-Protein	74 [view]
Protein-DNA	13 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000087	mitotic M phase
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006470	protein dephosphorylation
GO:0007067	mitotic nuclear division
GO:0008283	cell proliferation
GO:0009314	response to radiation
GO:0034644	cellular response to UV
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0051726	regulation of cell cycle