Version 5.4
Mus musculus Gene: Piwil1
Summary
InnateDB Gene IDBG-201648.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Piwil1
Gene Name piwi-like homolog 1 (Drosophila)
Synonyms MIWI
Species Mus musculus
Ensembl Gene ENSMUSG00000029423
Encoded Proteins
IDBP-201650
piwi-like homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125207:
This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:128736246-128755474
Strand Forward strand
Band G1.3
Transcripts
ENSMUST00000086056 ENSMUSP00000083222
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003727 single-stranded RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0034584 piRNA binding
Biological Process
GO:0006417 regulation of translation
GO:0007126 meiotic nuclear division
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0031047 gene silencing by RNA
GO:0034587 piRNA metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005844 polysome
GO:0005845 mRNA cap binding complex
GO:0033391 chromatoid body
GO:0043186 P granule
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000125207
View Gene Order
ENSBTAG00000006468
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04320
Dorso-ventral axis formation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04320
Dorso-ventral axis formation pathway
INOH
PID NCI
Cross-References
SwissProt Q9JMB7
TrEMBL
UniProt Splice Variant
Entrez Gene 57749
UniGene Mm.272720 Mm.470602
RefSeq NM_021311 XM_006504318 XM_006504319
OMIM
CCDS CCDS19690
HPRD
IMGT
MGI ID MGI:1928897
MGI Symbol Piwil1
EMBL AB032604 AF438405 BC066846 BC129857 BC129858 EF196092
GenPept AAH66846 AAI29858 AAI29859 AAL31014 ABM69181 BAA93705
RNA Seq Atlas 57749

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca