Version 5.4
Homo sapiens Gene: PIWIL1
Summary
InnateDB Gene IDBG-64637.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIWIL1
Gene Name piwi-like 1 (Drosophila)
Synonyms CT80.1; HIWI; MIWI; PIWI
Species Homo sapiens
Ensembl Gene ENSG00000125207
Encoded Proteins
IDBP-64639
piwi-like 1 (Drosophila)
IDBP-586932
piwi-like 1 (Drosophila)
IDBP-589333
piwi-like 1 (Drosophila)
IDBP-601088
piwi-like 1 (Drosophila)
IDBP-589886
piwi-like 1 (Drosophila)
IDBP-591465
piwi-like 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:130337887-130372637
Strand Forward strand
Band q24.33
Transcripts
ENST00000245255 ENSP00000245255
ENST00000546060 ENSP00000442086
ENST00000539400 ENSP00000440677
ENST00000539995 ENSP00000439096
ENST00000535956 ENSP00000444353
ENST00000542723 ENSP00000438582
ENST00000540672
ENST00000541480
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003727 single-stranded RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0034584 piRNA binding
Biological Process
GO:0006417 regulation of translation
GO:0007126 meiotic nuclear division
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0031047 gene silencing by RNA
GO:0034587 piRNA metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005844 polysome
GO:0005845 mRNA cap binding complex
GO:0033391 chromatoid body
GO:0043186 P granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029423
View Gene Order
ENSBTAG00000006468
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04320
Dorso-ventral axis formation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F5GYG0 F5GZL9 F5H2F7 F5H3U6 F5H889
UniProt Splice Variant
Entrez Gene 9271
UniGene Hs.405659
RefSeq NM_001190971 NM_004764 XM_005253632 XM_006719698
HUGO HGNC:9007
OMIM 605571
CCDS CCDS9268
HPRD 10409
IMGT
EMBL AC127071
GenPept
RNA Seq Atlas 9271

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca