Homo sapiens Gene: WARS | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-20170.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | WARS | ||||||||||||||||||||||
Gene Name | tryptophanyl-tRNA synthetase | ||||||||||||||||||||||
Synonyms | GAMMA-2; IFI53; IFP53 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000140105 | ||||||||||||||||||||||
Encoded Proteins |
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
tryptophanyl-tRNA synthetase
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 14:100333788-100376805 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q32.2 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Cytosolic tRNA aminoacylation pathway
tRNA Aminoacylation pathway
Gene Expression pathway
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KEGG |
Aminoacyl-tRNA biosynthesis pathway
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INOH |
Tryptophan degradation pathway
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PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | G3V2C0 G3V2F2 G3V313 G3V339 G3V3R3 G3V3S7 G3V3X0 G3V4C7 G3V4N8 G3V4S4 G3V5H5 G3V5W1 P78534 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 7453 | ||||||||||||||||||||||
UniGene | Hs.497599 Hs.736264 | ||||||||||||||||||||||
RefSeq | NM_004184 NM_173701 NM_213645 NM_213646 XM_005268044 XM_006720249 | ||||||||||||||||||||||
HUGO | HGNC:12729 | ||||||||||||||||||||||
OMIM | 191050 | ||||||||||||||||||||||
CCDS | CCDS9960 CCDS9961 | ||||||||||||||||||||||
HPRD | 01845 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AL135838 AL157871 S82904 | ||||||||||||||||||||||
GenPept | AAB39380 | ||||||||||||||||||||||
RNA Seq Atlas | 7453 | ||||||||||||||||||||||