InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WARS

Summary

InnateDB Protein

IDBP-598723.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WARS

Protein Name

tryptophanyl-tRNA synthetase

Synonyms

GAMMA-2; IFI53; IFP53;

Species

Homo sapiens

Ensembl Protein

ENSP00000451460

InnateDB Gene

IDBG-20170 (WARS)

Protein Structure

UniProt Annotation

Function

Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. {ECO:0000269PubMed:11773625, ECO:0000269PubMed:11773626, ECO:0000269PubMed:1373391, ECO:0000269PubMed:14630953}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004830	tryptophan-tRNA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0001525	angiogenesis
GO:0006412	translation
GO:0006418	tRNA aminoacylation for protein translation
GO:0006436	tryptophanyl-tRNA aminoacylation
GO:0008152	metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0010467	gene expression
GO:0045765	regulation of angiogenesis