InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fmo4

Summary

InnateDB Gene

IDBG-201986.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fmo4

Gene Name

flavin containing monooxygenase 4

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026692

Encoded Proteins

IDBP-201988

flavin containing monooxygenase 4

IDBP-257925

flavin containing monooxygenase 4

IDBP-541464

flavin containing monooxygenase 4

IDBP-541460

flavin containing monooxygenase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076258:
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jul 2008]
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:162793883-162813972

Strand

Reverse strand

Band

H2.1

Transcripts

ENSMUST00000028014	ENSMUSP00000028014
ENSMUST00000111525	ENSMUSP00000107150
ENSMUST00000140031
ENSMUST00000144916	ENSMUSP00000119389
ENSMUST00000140274	ENSMUSP00000118476

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004499	N,N-dimethylaniline monooxygenase activity
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0042737	drug catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005575	cellular_component
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000076258

View Gene Order

ENSBTAG00000016685

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00982

Drug metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00982

Drug metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.155164 Mm.452067

RefSeq

NM_144878 XM_006496773 XM_006496774 XM_006496775 XM_006496776 XM_006496777

OMIM

CCDS

CCDS15423

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas