Version 5.4
Mus musculus Gene: Flot2
Summary
InnateDB Gene IDBG-202091.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Flot2
Gene Name flotillin 2
Synonyms AI573412; Esa; reggie-2
Species Mus musculus
Ensembl Gene ENSMUSG00000061981
Encoded Proteins
IDBP-202095
flotillin 2
IDBP-202097
flotillin 2
IDBP-202099
flotillin 2
IDBP-623527
flotillin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132589:
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:78037931-78060434
Strand Forward strand
Band B5
Transcripts
ENSMUST00000073660 ENSMUSP00000073342
ENSMUST00000072289 ENSMUSP00000072136
ENSMUST00000100784 ENSMUSP00000098347
ENSMUST00000148162 ENSMUSP00000133147
ENSMUST00000136353
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005515 protein binding
GO:0035255 ionotropic glutamate receptor binding
Biological Process
GO:0007155 cell adhesion
GO:0010629 negative regulation of gene expression
GO:0050821 protein stabilization
GO:0090002 establishment of protein localization to plasma membrane
GO:1902992 negative regulation of amyloid precursor protein catabolic process
Cellular Component
GO:0002080 acrosomal membrane
GO:0005768 endosome
GO:0005901 caveola
GO:0016020 membrane
GO:0016600 flotillin complex
GO:0030139 endocytic vesicle
GO:0031982 vesicle
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000132589
View Gene Order
ENSBTAG00000010073
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04910
Insulin signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04910
Insulin signaling pathway pathway
INOH
PID NCI
p73pathway
p73 transcription factor network
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt Q60634
TrEMBL
UniProt Splice Variant
Entrez Gene 14252
UniGene Mm.130227
RefSeq NM_001284228 NM_008028 XM_006532192 XM_006532193 NM_001040403 XM_006532191 XM_006532194
OMIM
CCDS CCDS25088 CCDS36237
HPRD
IMGT
MGI ID MGI:103309
MGI Symbol Flot2
EMBL AK170557 AL669840 BC070423 CH466596 U07890
GenPept AAA93127 AAH70423 BAE41879 CAI25705 EDL12906
RNA Seq Atlas 14252

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca