InnateDB Protein
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IDBP-202099.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Flot2
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Protein Name
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flotillin 2
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Synonyms
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AI573412; Esa; reggie-2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000098347
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InnateDB Gene
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IDBG-202091 (Flot2)
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Protein Structure
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Function |
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Peripheral membrane protein {ECO:0000269PubMed:9153235}. Endosome {ECO:0000250}. Note=Membrane-associated protein of caveolae. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in many tissues, including suprabasal epidermis, hair follicles, heart, lung, thymus, spleen, liver, kidney and brain. Not expressed in skeletal muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
34 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0035255
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ionotropic glutamate receptor binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:103309
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InterPro |
IPR001107
Band 7 protein
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PFAM |
PF01145
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PRINTS |
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PIRSF |
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SMART |
SM00244
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TIGRFAMs |
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Modification |
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SwissProt |
Q60634
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PhosphoSite |
PhosphoSite-Q60634
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
14252
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UniGene |
Mm.130227
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RefSeq |
NP_032054
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MGI ID |
1WIN
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MGI Symbol |
Flot2
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OMIM |
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CCDS |
CCDS25088
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HPRD |
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IMGT |
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EMBL |
AK170557
AL669840
BC070423
CH466596
U07890
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GenPept |
AAA93127
AAH70423
BAE41879
CAI25705
EDL12906
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