Version 5.4
Mus musculus Gene: Setd2
Summary
InnateDB Gene IDBG-202203.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Setd2
Gene Name SET domain containing 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000044791
Encoded Proteins
IDBP-537752
SET domain containing 2
IDBP-627254
SET domain containing 2
IDBP-627249
SET domain containing 2
IDBP-627251
SET domain containing 2
IDBP-627252
SET domain containing 2
IDBP-627256
SET domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181555:
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:110532597-110618633
Strand Forward strand
Band F2
Transcripts
ENSMUST00000153838 ENSMUSP00000116313
ENSMUST00000156419
ENSMUST00000132532
ENSMUST00000130753 ENSMUSP00000134438
ENSMUST00000146345
ENSMUST00000173373 ENSMUSP00000134367
ENSMUST00000173288 ENSMUSP00000133925
ENSMUST00000173233 ENSMUSP00000134045
ENSMUST00000173272 ENSMUSP00000134574
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0018024 histone-lysine N-methyltransferase activity
Biological Process
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0001763 morphogenesis of a branching structure
GO:0001843 neural tube closure
GO:0006298 mismatch repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0010452 histone H3-K36 methylation
GO:0010468 regulation of gene expression
GO:0010793 regulation of mRNA export from nucleus
GO:0018023 peptidyl-lysine trimethylation
GO:0030900 forebrain development
GO:0034728 nucleosome organization
GO:0034968 histone lysine methylation
GO:0035441 cell migration involved in vasculogenesis
GO:0048332 mesoderm morphogenesis
GO:0048568 embryonic organ development
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048864 stem cell development
GO:0060039 pericardium development
GO:0060669 embryonic placenta morphogenesis
GO:0060977 coronary vasculature morphogenesis
GO:0097198 histone H3-K36 trimethylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000181555
View Gene Order
ENSBTAG00000002948
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00310
Lysine degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.288949 Mm.404631
RefSeq NM_001081340 XM_006512087 XM_006512088 XM_006512089 XM_006512090 XM_006512091 XM_006512092 XM_006512093 XM_006512094
OMIM
CCDS CCDS40781
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca