InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SCNN1G

Summary

InnateDB Gene

IDBG-20222.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCNN1G

Gene Name

sodium channel, non-voltage-gated 1, gamma subunit

Synonyms

BESC3; ENaCg; ENaCgamma; PHA1; SCNEG

Species

Homo sapiens

Ensembl Gene

ENSG00000166828

Encoded Proteins

IDBP-20224

sodium channel, nonvoltage-gated 1, gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:23182715-23216883

Strand

Forward strand

Band

p12.2

Transcripts

ENST00000300061

ENSP00000300061

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0015280	ligand-gated sodium channel activity
GO:0050699	WW domain binding

Biological Process

GO:0006814	sodium ion transport
GO:0007588	excretion
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0050891	multicellular organismal water homeostasis
GO:0050896	response to stimulus
GO:0050909	sensory perception of taste
GO:0055078	sodium ion homeostasis
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0034706	sodium channel complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000000216

View Gene Order

ENSBTAG00000010163

Not yet available

Pathways

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

hsa04742

Taste transduction pathway

hsa04960

Aldosterone-regulated sodium reabsorption pathway

INOH

PID NCI

Cross-References

SwissProt

P51170

TrEMBL

A5X2V1 Q6LCK5

UniProt Splice Variant

Entrez Gene

6340

UniGene

Hs.371727

RefSeq

NM_001039

HUGO

HGNC:10602

OMIM

600761

CCDS

CCDS10608

HPRD

02862

IMGT

EMBL

AF356493 AF356494 AF356495 AF356496 AF356497 AF356498 AF356499 AF356500 AF356501 AF356502 BC059391 BC069652 CH471145 DQ402524 FJ515832 L36592 U35630 U48936 U53836 U53837 U53841 U53844 U53845 U53846 U53847 U53848 U53850 U53852 X87160

GenPept

AAA75460 AAC50217 AAC50737 AAC50744 AAC50745 AAC50749 AAC50752 AAC50753 AAC50754 AAC50755 AAC50756 AAC50758 AAC50760 AAH59391 AAH69652 AAK50910 ABD72220 ACS13725 CAA60633 EAW55837 EAW55838

RNA Seq Atlas

6340