InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Traf4

Summary

InnateDB Gene

IDBG-202221.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Traf4

Gene Name

TNF receptor associated factor 4

Synonyms

A530032M13Rik; CART1; msp2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017386

Encoded Proteins

IDBP-202223

TNF receptor associated factor 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076604:
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:78158499-78165589

Strand

Reverse strand

Band

Transcripts

ENSMUST00000017530	ENSMUSP00000017530
ENSMUST00000149437
ENSMUST00000148218

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0031996	thioesterase binding
GO:0046872	metal ion binding
GO:0050699	WW domain binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0007585	respiratory gaseous exchange
GO:0016567	protein ubiquitination
GO:0030323	respiratory tube development
GO:0042981	regulation of apoptotic process
GO:0045860	positive regulation of protein kinase activity
GO:0046330	positive regulation of JNK cascade
GO:0090073	positive regulation of protein homodimerization activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000076604

View Gene Order

ENSBTAG00000038990

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu05222

Small cell lung cancer pathway

mmu05200

Pathways in cancer pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

hsa05222

Small cell lung cancer pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

tap63pathway

Validated transcriptional targets of TAp63 isoforms

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_009423

OMIM

CCDS

CCDS25090

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas