InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Traf4

Summary

InnateDB Protein

IDBP-202223.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Traf4

Protein Name

TNF receptor associated factor 4

Synonyms

A530032M13Rik; CART1; msp2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000017530

InnateDB Gene

IDBG-202221 (Traf4)

Protein Structure

UniProt Annotation

Function

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions (By similarity). Required for normal skeleton development, and for normal development of the respiratory tract. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in brain. Preferentially expressed by post-mitotic undifferentiated neurons in developing central (CNS) and peripheral (PNS) nervous system, and in nervous tissues of sensory organs. In the embryo, protein expression was shown in brain, thymus, salivary glands and intestine. In the adult, protein expression is restricted to the brain (hippocampus and olfactory bulb). {ECO:0000269PubMed:9507120}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0031996	thioesterase binding
GO:0046872	metal ion binding
GO:0050699	WW domain binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0007585	respiratory gaseous exchange
GO:0016567	protein ubiquitination
GO:0030323	respiratory tube development
GO:0042981	regulation of apoptotic process
GO:0045860	positive regulation of protein kinase activity
GO:0046330	positive regulation of JNK cascade
GO:0090073	positive regulation of protein homodimerization activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1202880

InterPro

IPR001293 Zinc finger, TRAF-type
IPR001841 Zinc finger, RING-type
IPR002083 MATH
IPR008974 TRAF-like
IPR012227 TNF receptor-associated factor TRAF
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF13639
PF14634
PF00917
PF00097

PRINTS

PIRSF

PIRSF015614

SMART

SM00184
SM00061

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt