Version 5.4
| Mus musculus Gene: Folr2 | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-202243.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Folr2 | ||||||
| Gene Name | folate receptor 2 (fetal) | ||||||
| Synonyms | FBP2; Folbp-2; Folbp2; FR-P3 | ||||||
| Species | Mus musculus | ||||||
| Ensembl Gene | ENSMUSG00000032725 | ||||||
| Encoded Proteins |
folate receptor 2 (fetal)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165457:
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008] The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68%% and 79%% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 7:101839990-101845331 | ||||||
| Strand | Reverse strand | ||||||
| Band | E2 | ||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
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Gene ID
Gene Order
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| Pathways | |||||||
| NETPATH | |||||||
| REACTOME | |||||||
| KEGG |
Endocytosis pathway
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| INOH | |||||||
| PID NCI | |||||||
| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH | |||||||
| REACTOME | |||||||
| KEGG |
Endocytosis pathway
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| INOH | |||||||
| PID NCI | |||||||
| Cross-References | |||||||
| SwissProt | Q05685 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 14276 | ||||||
| UniGene | |||||||
| RefSeq | NM_008035 XM_006507371 XM_006507373 | ||||||
| OMIM | |||||||
| CCDS | CCDS21516 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| MGI ID | MGI:95569 | ||||||
| MGI Symbol | Folr2 | ||||||
| EMBL | BC022108 L25338 M64817 | ||||||
| GenPept | AAA37594 AAA37599 AAH22108 | ||||||
| RNA Seq Atlas | 14276 | ||||||