Version 5.4
Homo sapiens Gene: FOLR2
Summary
InnateDB Gene IDBG-63326.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOLR2
Gene Name folate receptor 2 (fetal)
Synonyms BETA-HFR; FBP; FBP/PL-1; FR-BETA; FR-P3
Species Homo sapiens
Ensembl Gene ENSG00000165457
Encoded Proteins
IDBP-63328
folate receptor 2 (fetal)
IDBP-63330
folate receptor 2 (fetal)
IDBP-380299
folate receptor 2 (fetal)
IDBP-380300
folate receptor 2 (fetal)
IDBP-592064
folate receptor 2 (fetal)
IDBP-592275
folate receptor 2 (fetal)
IDBP-603818
folate receptor 2 (fetal)
IDBP-584189
folate receptor 2 (fetal)
IDBP-591581
folate receptor 2 (fetal)
IDBP-813749
folate receptor 2 (fetal)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68%% and 79%% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:72216601-72221950
Strand Forward strand
Band q13.4
Transcripts
ENST00000298223 ENSP00000298223
ENST00000321324 ENSP00000321957
ENST00000454954 ENSP00000414094
ENST00000449475 ENSP00000405638
ENST00000541003 ENSP00000443307
ENST00000539412 ENSP00000441547
ENST00000536778 ENSP00000438568
ENST00000535625 ENSP00000444794
ENST00000538353 ENSP00000440337
ENST00000619261 ENSP00000480592
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005542 folic acid binding
GO:0008517 folic acid transporter activity
Biological Process
GO:0015884 folic acid transport
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
GO:0031362 anchored component of external side of plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000032725
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.433159
RefSeq NM_000803 NM_001113534 NM_001113535 NM_001113536 XM_005273856
HUGO
OMIM
CCDS CCDS8212
HPRD 00637
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca